ANAPC4

Across TCGA pan-cancer cohorts, ANAPC4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ANAPC4 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ANAPC4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ANAPC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, BLCA, and KIRC are the cancer types where ANAPC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.793	0.510	<.001	110	view →
BLCA	OS	Median	All	0.680	0.535	<.001	77	view →
KIRC	DFS	Tertile	III,IV	0.282	0.613	<.001	64	view →
UCS	DFS	Quartile	III,IV	0.533	0.096	.012	46	view →
SKCM	DFS	Quartile	All	0.271	0.144	<.001	45	view →
KICH	DFS	Quartile	II,III,IV	0.460	0.957	.003	44	view →
LIHC	OS	Quartile	II,III,IV	0.348	0.684	<.001	44	view →
UVM	DFS	Quartile	III,IV	0.170	0.832	<.001	41	view →
LGG	DFS	Median	All	0.662	0.811	<.001	41	view →
THYM	DFS	Quartile	All	0.913	0.541	.002	29	view →
READ	OS	Median	II,III,IV	0.765	0.309	.003	22	view →
LUAD	OS	Quartile	All	0.895	0.698	.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ANAPC4–UCEC (OS)

Open the UCEC breakdown →