ANAPC4

Across TCGA patient cohorts, ANAPC4 mutation is significantly associated with the RNA expression of many other genes, with 2,387 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC4-associated genes across cancer lineages are TSPY24P, RNU6-1158P, and RNY4P20. Each is linked with ANAPC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANAPC4-to-partner and partner-to-ANAPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY24P grouped by ANAPC4-low versus ANAPC4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC4→partner) and Y-score (partner→ANAPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TSPY24P →	+0.358	+4.548	<.001	.009	3	3
COAD	RNU6-1158P →	+0.409	+5.080	.008	.008	3	3
SKCM	RNY4P20 →	+0.185	+3.858	<.001	.001	3	2
SKCM	LINC02695 →	+0.240	+2.694	.007	.004	3	2
LUSC	MIR1268B →	+1.313	+4.447	<.001	.006	3	2
READ	CDY3P →	+0.037	+6.276	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,387 associations by consensus.

TSPY24P by ANAPC4 expression — LUSC

Explore this box plot interactively →