ANAPC4

Across TCGA patient cohorts, ANAPC4 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC4-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and ASNS. Each is linked with ANAPC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANAPC4-to-partner and partner-to-ANAPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ANAPC4-low versus ANAPC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC4→partner) and Y-score (partner→ANAPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.200	+1.906	.021	.016	3	3
UCEC	Caspase-7-cleavedD198 →	+0.502	+1.604	.035	.041	3	3
UCEC	ASNS →	+0.722	+3.807	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.091	-1.979	.023	.030	3	1
UCEC	eIF4E →	+0.176	+2.820	.038	.035	3	1
UCEC	eIF4G →	+0.308	+3.169	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PCNA by ANAPC4 expression — UCEC

Explore this box plot interactively →