ANAPC4

Across TCGA cell cohorts, ANAPC4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ANAPC4-associated genes across cancer lineages are REG1B, SPINK9, and OR11G2. Each is linked with ANAPC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC4-to-partner and partner-to-ANAPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by ANAPC4-low versus ANAPC4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC4→partner) and Y-score (partner→ANAPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	2
LARGE_INTESTINE	SPINK9 →	+0.329	+3.793	<.001	.007	3	1
SKIN	OR11G2 →	+0.008	+3.930	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

REG1B by ANAPC4 expression — BREAST

Explore this box plot interactively →