ANAPC10

Across TCGA patient cohorts, ANAPC10 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC10-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and Rab11. Each is linked with ANAPC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC10-to-partner and partner-to-ANAPC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ANAPC10-low versus ANAPC10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC10→partner) and Y-score (partner→ANAPC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.211	-3.169	.009	.019	3	1
UCEC	Notch1 →	+0.198	+2.179	.003	.034	3	1
UCEC	Rab11 →	-0.171	-3.150	.014	.019	3	1
UCEC	Rab25 →	-0.395	-2.459	.013	.020	3	1
UCEC	STAT3_pY705 →	-0.551	-3.311	<.001	.010	3	1
UCEC	Tuberin →	+0.342	+2.459	.008	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK_pT183_Y185 by ANAPC10 expression — UCEC

Explore this box plot interactively →