ANAPC10

Across TCGA pan-cancer cohorts, ANAPC10 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ANAPC10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ANAPC10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANAPC10 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where ANAPC10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANAPC10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.680	<.001	12	view →
LIHC	All	III,IV	+0.452	<.001	9	view →
THCA	Male	All	−0.301	<.001	8	view →
KICH	Female	All	−0.823	<.001	6	view →
STAD	All	II,III,IV	+0.500	.002	6	view →
COAD	Male	All	+0.500	<.001	4	view →
CHOL	All	All	+1.041	<.001	3	view →
ESCA	All	All	+0.625	<.001	3	view →
LUAD	Female	III,IV	−0.511	.001	3	view →
LUSC	Male	III,IV	−0.497	.016	2	view →
UCEC	All	All	−0.383	.015	2	view →
KIRP	Male	All	−0.292	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ANAPC10–HNSC

Open the HNSC breakdown →