ANAPC1

Across TCGA patient cohorts, ANAPC1 mutation is significantly associated with the RNA expression of many other genes, with 2,365 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC1-associated genes across cancer lineages are BIVM-ERCC5, MIR4705, and VDAC1. Each is linked with ANAPC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANAPC1-to-partner and partner-to-ANAPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BIVM-ERCC5 grouped by ANAPC1-low versus ANAPC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC1→partner) and Y-score (partner→ANAPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BIVM-ERCC5 →	+0.018	+2.909	.003	<.001	3	3
STAD	MIR4705 →	+0.702	+5.070	<.001	.004	3	3
UCEC	VDAC1 →	+0.334	+1.909	.002	<.001	3	3
UCEC	USP9YP2 →	+0.007	+3.673	<.001	.006	3	3
BLCA	CHEK2P1 →	+0.043	+3.870	<.001	.009	3	3
LUAD	RNA5SP146 →	+0.351	+3.787	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,365 associations by consensus.

BIVM-ERCC5 by ANAPC1 expression — SKCM

Explore this box plot interactively →