AMY2A

Across TCGA patient cohorts, AMY2A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMY2A-associated genes across cancer lineages are A-Raf_pS299, JNK2, and Ku80. Each is linked with AMY2A in more than 1 cancer types. Because this analysis shows association rather than direction, both AMY2A-to-partner and partner-to-AMY2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by AMY2A-low versus AMY2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMY2A→partner) and Y-score (partner→AMY2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.139	-2.700	.002	.006	3	2
UCEC	JNK2 →	+0.164	+1.884	.031	.030	3	2
UCEC	Ku80 →	+0.266	+1.691	.003	.014	3	2
UCEC	Cyclin-E2 →	+0.132	+1.678	.040	.023	3	2
UCEC	EGFR_pY1068 →	-0.256	-2.087	.007	.005	3	1
UCEC	FoxM1 →	+0.243	+3.247	.014	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

A-Raf_pS299 by AMY2A expression — UCEC

Explore this box plot interactively →