AMY1A

Across TCGA cell cohorts, AMY1A RNA expression is significantly associated with the go_rna of many other GO terms, with 99 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AMY1A-associated GO terms across cancer lineages are Regulation of intrinsic apoptotic signaling pathway, Maintenance of protein location in mitochondrion, and Pentose-phosphate shunt, oxidative branch. Each is linked with AMY1A in more than 2 cancer types. Because this analysis shows association rather than direction, both AMY1A-to-partner and partner-to-AMY1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intrinsic apoptotic signaling pathway grouped by AMY1A-low versus AMY1A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMY1A→partner) and Y-score (partner→AMY1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of intrinsic apoptotic signaling pathway →	+0.053	+0.048	.003	.007	3	3
UPPER_AERODIGESTIVE_TRACT	Maintenance of protein location in mitochondrion →	+0.121	+0.033	.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	Pentose-phosphate shunt, oxidative branch →	+0.087	+0.033	.005	.007	3	2
SOFT_TISSUE	Behavioral response to pain →	+0.182	+0.010	.003	.007	2	3
SOFT_TISSUE	Otic vesicle morphogenesis →	-0.693	-0.010	.005	.009	3	2
SOFT_TISSUE	Regulation of translation at synapse, modulating synaptic transmission →	+0.088	+0.019	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

Regulation of intrinsic apoptotic signaling pathway by AMY1A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →