Across TCGA patient cohorts, AMTN mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMTN-associated genes across cancer lineages are Caspase-8, JNK_pT183_Y185, and Rab11. Each is linked with AMTN in more than 1 cancer types. Because this analysis shows association rather than direction, both AMTN-to-partner and partner-to-AMTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMTN→partner) and Y-score (partner→AMTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Caspase-8 →	-0.239	-3.000	.003	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.207	-3.156	.025	.020	3	1
UCEC	Rab11 →	-0.177	-3.169	.026	.020	3	1
UCEC	STAT3_pY705 →	-0.575	-3.169	<.001	.020	3	1
UCEC	Tuberin →	+0.409	+3.169	.005	.020	3	1
SKCM	ACVRL1 →	+0.165	+3.000	.038	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

AMTN survival (RNA) · tumor vs normal (RNA) · all AMTN data types