Across TCGA pan-cancer cohorts, AMTN RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of AMTN’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AMTN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AMTN is over-expressed in tumor, although a few such as KIRC and STAD show the opposite, repressed pattern.
HNSC, KIRC, and LUSC are the cancer types where AMTN tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMTN RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.