Across TCGA cell cohorts, AMTN mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AMTN-associated genes across cancer lineages are C20orf85, OR6K6, and MBD3L5. Each is linked with AMTN in more than 1 cancer types. Because this analysis shows association rather than direction, both AMTN-to-partner and partner-to-AMTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMTN→partner) and Y-score (partner→AMTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C20orf85 →	+0.045	+4.930	<.001	.001	3	1
SKIN	OR6K6 →	+0.014	+4.415	.001	.007	3	1
SKIN	MBD3L5 →	+0.016	+4.415	<.001	.007	3	1
SKIN	GH1 →	+0.036	+4.415	<.001	.007	3	1
SKIN	H4C12 →	+1.516	+4.273	<.001	.006	3	1
SKIN	AMELY →	+0.024	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

AMTN survival (RNA) · tumor vs normal (RNA) · all AMTN data types