AMT

Across TCGA pan-cancer cohorts, AMT mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated AMT data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AMT mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AMT expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where AMT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	1.000	0.751	.029	36	view →
PDAC	OS	Tertile	II,III,IV	0.694	0.405	.017	11	view →
HNSC	DFS	Median	IV	0.905	0.557	.015	6	view →
LUAD	OS	Median	All	0.934	0.570	.021	5	view →
UCEC	OS	Quartile	II,III,IV	0.547	1.000	.042	4	view →
LSCC	DFS	Quartile	II,III,IV	0.572	0.890	.029	3	view →
GBM	OS	Median	All	0.465	0.289	.049	2	view →
CCRCC	OS	Median	All	1.000	0.763	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

AMT–COAD (DFS)

Open the COAD breakdown →