AMPH

Across TCGA cell cohorts, AMPH mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMPH-associated genes across cancer lineages are LRRC10, OR2J3, and HTR3B. Each is linked with AMPH in more than 1 cancer types. Because this analysis shows association rather than direction, both AMPH-to-partner and partner-to-AMPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC10 grouped by AMPH-low versus AMPH-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPH→partner) and Y-score (partner→AMPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LRRC10 →	+0.013	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	OR2J3 →	+0.019	+4.867	<.001	.009	3	1
PANCREAS	HTR3B →	+0.018	+4.237	.002	.006	3	1
PANCREAS	BPIFB3 →	+0.052	+4.614	<.001	.004	3	1
PANCREAS	C3orf85 →	+0.197	+5.584	<.001	<.001	3	1
LUNG_NSCLC_LUSC	MTRNR2L1 →	+0.050	+3.129	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

LRRC10 by AMPH expression — OESOPHAGUS

Explore this box plot interactively →