AMPD2

Across TCGA patient cohorts, AMPD2 mutation is significantly associated with the RNA expression of many other genes, with 2,296 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMPD2-associated genes across cancer lineages are TRIM35, LRRC59, and FAM114A1. Each is linked with AMPD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AMPD2-to-partner and partner-to-AMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM35 grouped by AMPD2-low versus AMPD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPD2→partner) and Y-score (partner→AMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM35 →	+0.340	+1.727	.003	.006	3	3
UCEC	LRRC59 →	+0.348	+1.934	.008	.002	3	3
COAD	FAM114A1 →	+0.687	+3.469	<.001	.002	3	3
COAD	SRA1 →	+0.359	+3.262	.002	.008	3	3
UCEC	RCC1 →	+0.361	+1.896	.006	.004	3	3
UCEC	TAF13 →	+0.436	+2.008	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,296 associations by consensus.

TRIM35 by AMPD2 expression — UCEC

Explore this box plot interactively →