AMOTL2

Across TCGA cell cohorts, AMOTL2 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMOTL2-associated genes across cancer lineages are DNASE2B, OR13C3, and PNMA6F. Each is linked with AMOTL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMOTL2-to-partner and partner-to-AMOTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNASE2B grouped by AMOTL2-low versus AMOTL2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOTL2→partner) and Y-score (partner→AMOTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DNASE2B →	+0.211	+3.584	.004	.009	3	2
LUNG_NSCLC_LUAD	OR13C3 →	+0.022	+4.887	<.001	.009	3	2
STOMACH	PNMA6F →	+0.005	+3.662	<.001	.001	3	2
PANCREAS	CABP2 →	+0.026	+5.614	<.001	.002	3	1
PANCREAS	KCNG4 →	+0.013	+5.614	<.001	.002	3	1
PANCREAS	HMGB4 →	+0.022	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

DNASE2B by AMOTL2 expression — URINARY_TRACT

Explore this box plot interactively →