AMOTL1

Across TCGA cell cohorts, AMOTL1 mutation is significantly associated with the RNA expression of many other genes, with 270 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMOTL1-associated genes across cancer lineages are GAGE13, RABGGTB, and TBC1D3. Each is linked with AMOTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMOTL1-to-partner and partner-to-AMOTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE13 grouped by AMOTL1-low versus AMOTL1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOTL1→partner) and Y-score (partner→AMOTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GAGE13 →	+1.534	+3.518	.004	.008	3	2
LARGE_INTESTINE	RABGGTB →	+0.663	+2.502	.002	.005	3	2
LARGE_INTESTINE	TBC1D3 →	+0.053	+2.465	<.001	.001	3	2
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 270 associations by consensus.

GAGE13 by AMOTL1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →