AMOT

Across TCGA patient cohorts, AMOT mutation is significantly associated with the RNA expression of many other genes, with 6,139 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMOT-associated genes across cancer lineages are EDEM1, NUP58, and TMF1. Each is linked with AMOT in more than 3 cancer types. Because this analysis shows association rather than direction, both AMOT-to-partner and partner-to-AMOT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EDEM1 grouped by AMOT-low versus AMOT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOT→partner) and Y-score (partner→AMOT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EDEM1 →	+0.473	+1.362	<.001	<.001	3	4
UCEC	NUP58 →	+0.503	+1.488	<.001	<.001	3	4
UCEC	TMF1 →	+0.312	+1.478	.009	<.001	3	4
UCEC	ERCC6L2 →	+0.272	+1.564	.002	.004	3	4
UCEC	RRM2 →	+0.869	+3.080	<.001	<.001	3	4
UCEC	SLC4A7 →	+0.415	+1.726	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,139 associations by consensus.

EDEM1 by AMOT expression — UCEC

Explore this box plot interactively →