AMOT

Across TCGA pan-cancer cohorts, AMOT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of AMOT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AMOT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AMOT is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

COAD, HNSC, and THCA are the cancer types where AMOT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMOT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.875	<.001	11	view →
HNSC	All	IV	−1.855	<.001	10	view →
THCA	Male	III,IV	+1.081	<.001	8	view →
BRCA	Female	All	−0.553	<.001	6	view →
KICH	All	II,III,IV	−0.823	.005	5	view →
BLCA	Male	All	−1.611	.001	4	view →
LIHC	All	All	+0.453	.008	4	view →
CHOL	All	All	+1.541	<.001	3	view →
PRAD	All	All	−0.702	<.001	2	view →
STAD	Male	All	+0.543	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

AMOT–COAD

Open the COAD breakdown →