AMOT

Across TCGA patient cohorts, AMOT mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMOT-associated genes across cancer lineages are 4E-BP1, PCNA, and PDCD4. Each is linked with AMOT in more than 4 cancer types. Because this analysis shows association rather than direction, both AMOT-to-partner and partner-to-AMOT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by AMOT-low versus AMOT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOT→partner) and Y-score (partner→AMOT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.328	+3.169	.024	.018	2	5
UCEC	PCNA →	+0.188	+2.584	.001	<.001	3	3
UCEC	PDCD4 →	-0.378	-1.047	.002	.018	3	3
UCEC	Cyclin-B1 →	+0.671	+2.874	<.001	<.001	3	3
BLCA	eIF4G →	+0.418	+3.000	.046	.036	3	2
BLCA	GSK-3_pS9 →	-0.361	-3.000	.038	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

4E-BP1 by AMOT expression — SKCM

Explore this box plot interactively →