AMOT

Across TCGA cell cohorts, AMOT mutation is significantly associated with the RNA expression of many other genes, with 351 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMOT-associated genes across cancer lineages are CT45A7, DCAF11, and BCDIN3D. Each is linked with AMOT in more than 1 cancer types. Because this analysis shows association rather than direction, both AMOT-to-partner and partner-to-AMOT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT45A7 grouped by AMOT-low versus AMOT-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOT→partner) and Y-score (partner→AMOT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CT45A7 →	+0.074	+4.209	<.001	.006	3	2
LARGE_INTESTINE	DCAF11 →	+0.567	+3.502	.002	.001	3	2
LARGE_INTESTINE	BCDIN3D →	+0.543	+3.082	<.001	.007	3	2
LARGE_INTESTINE	FBF1 →	+0.918	+3.169	.001	.009	3	2
CNS	EVPLL →	+0.427	+4.096	.007	.001	3	2
KIDNEY	ZNF735 →	+0.023	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 351 associations by consensus.

CT45A7 by AMOT expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →