AMN

Across TCGA cell cohorts, AMN mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMN-associated genes across cancer lineages are NEUROD4, CLDN34, and NXPH2. Each is linked with AMN in more than 1 cancer types. Because this analysis shows association rather than direction, both AMN-to-partner and partner-to-AMN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROD4 grouped by AMN-low versus AMN-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMN→partner) and Y-score (partner→AMN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NEUROD4 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CLDN34 →	+0.043	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	NXPH2 →	+0.030	+4.867	.003	.009	3	1
BLOOD_Lymphoma	USP17L4 →	+0.013	+5.209	<.001	.005	3	1
LARGE_INTESTINE	CPO →	+0.150	+3.514	<.001	.007	3	1
LARGE_INTESTINE	TFDP3 →	+0.018	+3.518	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

NEUROD4 by AMN expression — BLOOD_Myeloma

Explore this box plot interactively →