AMN

Across TCGA pan-cancer cohorts, AMN RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of AMN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AMN RNA is repressed in tumor relative to normal tissue. In most cancer types AMN is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and THCA are the cancer types where AMN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−4.207	<.001	10	view →
COAD	Female	II,III,IV	−1.619	<.001	10	view →
THCA	Male	III,IV	−0.970	<.001	10	view →
LUSC	All	II,III,IV	+0.955	<.001	8	view →
BLCA	All	All	+1.077	.002	6	view →
READ	Male	All	−2.280	.027	4	view →
CHOL	All	All	−2.525	<.001	2	view →
PAAD	All	All	+2.325	.008	2	view →
LIHC	All	All	−0.936	.010	2	view →
HNSC	Male	All	+0.653	.012	2	view →
LUAD	All	II,III,IV	+0.611	.017	2	view →
PRAD	All	All	−0.329	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

AMN–KICH

Open the KICH breakdown →