AMIGO3

Across TCGA patient cohorts, AMIGO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,730 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible AMIGO3-associated GO terms across cancer lineages are Depyrimidination, Protein methylation, and Negative regulation of gene expression, epigenetic. Each is linked with AMIGO3 in more than 21 cancer types. Because this analysis shows association rather than direction, both AMIGO3-to-partner and partner-to-AMIGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Depyrimidination grouped by AMIGO3-low versus AMIGO3-high in KIRP.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO3→partner) and Y-score (partner→AMIGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	Depyrimidination →	+0.049	+0.054	<.001	<.001	3	22
SCLC	Protein methylation →	+0.094	+0.994	<.001	<.001	3	22
SCLC	Negative regulation of gene expression, epigenetic →	+0.090	+0.851	<.001	<.001	3	21
SCLC	Positive regulation of DNA metabolic process →	+0.041	+0.665	<.001	<.001	3	21
SCLC	Regulation of DNA repair →	+0.037	+0.875	<.001	<.001	3	21
SCLC	Nucleotide-excision repair →	+0.060	+0.649	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,730 associations by consensus.

Depyrimidination by AMIGO3 expression — KIRP

Explore this box plot interactively →