AMIGO3

Across TCGA pan-cancer cohorts, AMIGO3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated AMIGO3 data layer compared with 6 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher AMIGO3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AMIGO3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

DLBC, HNSC, and KIRP are the cancer types where AMIGO3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	II,III,IV	0.403	1.000	.001	52	view →
HNSC	OS	Quartile	All	0.855	0.719	.002	51	view →
KIRP	DFS	Quartile	All	0.969	0.849	.005	32	view →
LGG	DFS	Median	All	0.772	0.875	<.001	32	view →
ACC	OS	Median	II,III,IV	0.739	0.948	.004	31	view →
KIRC	DFS	Quartile	II,III,IV	0.381	0.599	.003	29	view →
THYM	DFS	Median	II,III,IV	0.957	0.821	.003	26	view →
LUSC	DFS	Median	III,IV	0.432	0.948	.003	24	view →
SCLC	OS	Median	II,III,IV	1.000	0.501	.012	21	view →
STAD	DFS	Tertile	IV	0.170	0.614	.007	21	view →
LIHC	OS	Tertile	All	0.681	0.838	.002	20	view →
SKCM	DFS	Median	IV	0.954	0.134	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

AMIGO3–DLBC (DFS)

Open the DLBC breakdown →