AMIGO3

Across TCGA patient cohorts, AMIGO3 mutation is significantly associated with the RNA expression of many other genes, with 1,607 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMIGO3-associated genes across cancer lineages are SOD2, CHMP7, and KIR3DL1. Each is linked with AMIGO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMIGO3-to-partner and partner-to-AMIGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOD2 grouped by AMIGO3-low versus AMIGO3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO3→partner) and Y-score (partner→AMIGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SOD2 →	+0.828	+3.335	<.001	.005	3	2
UCEC	CHMP7 →	+0.531	+2.180	<.001	<.001	3	2
COAD	KIR3DL1 →	+0.194	+2.761	.003	.006	3	2
COAD	TIMM22 →	+0.445	+3.199	.004	.009	3	2
COAD	KIR3DL2 →	+0.338	+2.929	<.001	.005	3	2
COAD	MTND3P13 →	+0.101	+3.478	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,607 associations by consensus.

SOD2 by AMIGO3 expression — COAD

Explore this box plot interactively →