AMIGO3

Across TCGA patient cohorts, AMIGO3 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMIGO3-associated genes across cancer lineages are ATM, mTOR, and PKC-b-II_pS660. Each is linked with AMIGO3 in more than 3 cancer types. Because this analysis shows association rather than direction, both AMIGO3-to-partner and partner-to-AMIGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by AMIGO3-low versus AMIGO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO3→partner) and Y-score (partner→AMIGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.403	-3.156	.018	.018	3	4
UCEC	mTOR →	-0.142	-1.765	.019	.014	3	3
COAD	PKC-b-II_pS660 →	-0.499	-2.991	.006	.036	3	3
UCEC	EGFR_pY1068 →	-0.248	-3.321	.008	.009	3	2
COAD	PDCD4 →	-0.573	-2.991	.008	.036	2	3
UCEC	Shc_pY317 →	-0.156	-1.906	.006	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by AMIGO3 expression — UCEC

Explore this box plot interactively →