AMIGO3

Across TCGA cell cohorts, AMIGO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,750 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AMIGO3-associated GO terms across cancer lineages are Negative regulation of RNA splicing, Lysosome organization, and Lytic vacuole organization. Each is linked with AMIGO3 in more than 12 cancer types. Because this analysis shows association rather than direction, both AMIGO3-to-partner and partner-to-AMIGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA splicing grouped by AMIGO3-low versus AMIGO3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO3→partner) and Y-score (partner→AMIGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of RNA splicing →	+0.091	+0.667	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Lysosome organization →	+0.051	+0.297	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Lytic vacuole organization →	+0.051	+0.297	<.001	<.001	3	13
BONE	Microtubule nucleation →	+0.129	+0.883	<.001	<.001	3	12
PANCREAS	Establishment of mitotic spindle localization →	+0.073	+0.480	.003	.005	3	12
LUNG_NSCLC_LUSC	Aromatic amino acid family catabolic process →	-0.264	-0.717	.002	.009	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,750 associations by consensus.

Negative regulation of RNA splicing by AMIGO3 expression — URINARY_TRACT

Explore this box plot interactively →