AMIGO3

Across TCGA cell cohorts, AMIGO3 mutation is significantly associated with the RNA expression of many other genes, with 271 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMIGO3-associated genes across cancer lineages are CBY1, DHDH, and ZNF330. Each is linked with AMIGO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMIGO3-to-partner and partner-to-AMIGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by AMIGO3-low versus AMIGO3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO3→partner) and Y-score (partner→AMIGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.767	+3.299	<.001	.004	3	1
LARGE_INTESTINE	DHDH →	+0.568	+3.212	.006	.006	3	1
LARGE_INTESTINE	ZNF330 →	+0.541	+3.212	.002	.006	3	1
LARGE_INTESTINE	VEGFA →	+1.453	+3.212	<.001	.006	3	1
LARGE_INTESTINE	WRAP73 →	+0.584	+3.212	.002	.006	3	1
LARGE_INTESTINE	SYF2 →	+0.562	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 271 associations by consensus.

CBY1 by AMIGO3 expression — LARGE_INTESTINE

Explore this box plot interactively →