AMIGO2

Across TCGA patient cohorts, AMIGO2 mutation is significantly associated with the RNA expression of many other genes, with 1,032 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMIGO2-associated genes across cancer lineages are MIR4797, TBC1D3P1-DHX40P1, and RN7SL37P. Each is linked with AMIGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMIGO2-to-partner and partner-to-AMIGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4797 grouped by AMIGO2-low versus AMIGO2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO2→partner) and Y-score (partner→AMIGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4797 →	+0.819	+5.054	<.001	.001	3	2
READ	TBC1D3P1-DHX40P1 →	+0.230	+4.925	<.001	.004	3	2
SKCM	RN7SL37P →	+0.073	+1.671	.001	.006	3	2
LGG	RNA5SP423 →	+0.353	+7.977	<.001	.007	3	2
COAD	OR2U1P →	+0.042	+4.136	<.001	.008	3	2
COAD	RN7SL38P →	+0.580	+3.220	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,032 associations by consensus.

MIR4797 by AMIGO2 expression — READ

Explore this box plot interactively →