AMIGO1

Across TCGA patient cohorts, AMIGO1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,389 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AMIGO1-associated genes across cancer lineages are PRODH, CRYBB3, and RASL10A. Each is linked with AMIGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMIGO1-to-partner and partner-to-AMIGO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AMIGO1 versus PRODH in GBM, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO1→partner) and Y-score (partner→AMIGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.694	+0.415	<.001	<.001	3	1
GBM	CRYBB3 →	+0.429	+0.328	.002	.001	3	1
GBM	RASL10A →	+0.790	+0.426	.001	<.001	3	1
GBM	CBX7 →	+0.556	+0.415	.001	<.001	3	1
GBM	SYNGR1 →	+1.080	+0.487	<.001	<.001	3	1
GBM	PNPLA5 →	+0.157	+0.306	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,389 associations by consensus.

AMIGO1 vs PRODH — GBM

Explore this scatter interactively →