AMIGO1

Across TCGA pan-cancer cohorts, AMIGO1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AMIGO1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AMIGO1 RNA is repressed in tumor relative to normal tissue. In most cancer types AMIGO1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and THCA are the cancer types where AMIGO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMIGO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.007	<.001	10	view →
LUAD	Female	III,IV	−1.393	<.001	9	view →
THCA	Male	All	−0.562	<.001	8	view →
LUSC	Female	II,III,IV	−1.865	<.001	7	view →
LIHC	All	II,III,IV	+0.802	<.001	7	view →
HNSC	All	All	−0.675	<.001	7	view →
UCEC	All	All	−1.201	<.001	6	view →
BRCA	Female	II,III,IV	−0.854	<.001	6	view →
CHOL	Female	All	+2.223	<.001	3	view →
KIRC	Female	All	+0.607	.008	3	view →
KIRP	All	All	−0.541	.003	2	view →
BLCA	Male	IV	−1.599	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AMIGO1–KICH

Open the KICH breakdown →