AMIGO1

Across TCGA patient cohorts, AMIGO1 mutation is significantly associated with the RNA expression of many other genes, with 1,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMIGO1-associated genes across cancer lineages are RN7SKP221, BEND7, and BTNL9. Each is linked with AMIGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMIGO1-to-partner and partner-to-AMIGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP221 grouped by AMIGO1-low versus AMIGO1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO1→partner) and Y-score (partner→AMIGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
UCEC	BEND7 →	-0.838	-3.044	.001	<.001	3	2
UCEC	BTNL9 →	-0.945	-3.438	.004	.005	3	2
UCEC	TMEM126A →	+0.524	+3.087	<.001	<.001	3	2
UCEC	ZNF57 →	+0.454	+2.425	<.001	.002	3	2
UCEC	BDNF →	+0.486	+2.601	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,350 associations by consensus.

RN7SKP221 by AMIGO1 expression — BRCA

Explore this box plot interactively →