AMIGO1

Across TCGA patient cohorts, AMIGO1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMIGO1-associated genes across cancer lineages are STAT5a, c-Met_pY1235, and IGFBP2. Each is linked with AMIGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMIGO1-to-partner and partner-to-AMIGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by AMIGO1-low versus AMIGO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO1→partner) and Y-score (partner→AMIGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.520	+3.169	.003	.019	3	2
SKCM	c-Met_pY1235 →	-0.104	-3.000	.031	.036	3	1
UCEC	IGFBP2 →	-0.750	-2.000	.010	.032	3	1
UCEC	JNK2 →	+0.279	+2.000	.001	.032	3	1
UCEC	Notch1 →	+0.223	+2.000	<.001	.032	3	1
UCEC	p21 →	+0.211	+3.013	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

STAT5a by AMIGO1 expression — UCEC

Explore this box plot interactively →