AMBRA1

Across TCGA cell cohorts, AMBRA1 mutation is significantly associated with the RNA expression of many other genes, with 449 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMBRA1-associated genes across cancer lineages are MYMK, OR1L4, and DAZ4. Each is linked with AMBRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMBRA1-to-partner and partner-to-AMBRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYMK grouped by AMBRA1-low versus AMBRA1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBRA1→partner) and Y-score (partner→AMBRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MYMK →	+0.046	+4.285	<.001	.003	3	1
URINARY_TRACT	OR1L4 →	+0.080	+5.087	<.001	.004	3	1
URINARY_TRACT	DAZ4 →	+0.013	+5.087	<.001	.004	3	1
OESOPHAGUS	KHDC3L →	+0.046	+4.017	.007	.007	3	1
LARGE_INTESTINE	PICK1 →	+0.636	+3.169	.004	.009	3	1
LARGE_INTESTINE	RANBP9 →	+0.536	+3.321	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 449 associations by consensus.

MYMK by AMBRA1 expression — BLOOD_Myeloma

Explore this box plot interactively →