AMBP

Across TCGA pan-cancer cohorts, AMBP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated AMBP data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher AMBP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AMBP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where AMBP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.876	0.432	.001	46	view →
LUAD	OS	Tertile	III,IV	0.358	1.000	.006	29	view →
LSCC	OS	Median	All	0.922	1.000	.011	12	view →
GBM	OS	Quartile	All	0.908	0.652	.016	7	view →
UCEC	DFS	Tertile	III,IV	0.409	1.000	.020	4	view →
HNSC	OS	Tertile	All	0.952	1.000	.035	3	view →
PDAC	DFS	Quartile	III,IV	0.397	0.894	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

AMBP–CCRCC (DFS)

Open the CCRCC breakdown →