AMBP

Across TCGA pan-cancer cohorts, AMBP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AMBP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AMBP RNA is repressed in tumor relative to normal tissue. In most cancer types AMBP is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and THCA are the cancer types where AMBP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMBP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.961	<.001	11	view →
KIRC	Male	All	−2.076	<.001	11	view →
THCA	Male	III,IV	−1.057	<.001	10	view →
COAD	All	All	+0.735	<.001	10	view →
LUSC	Male	II,III,IV	−0.934	<.001	6	view →
LIHC	All	All	−0.916	.001	5	view →
CHOL	Male	All	−4.501	<.001	2	view →
LUAD	Male	III,IV	−1.411	.012	2	view →
KIRP	All	All	−1.210	<.001	2	view →
READ	Female	All	+0.984	.003	1	view →
STAD	All	All	+0.479	.037	1	view →
BLCA	Female	IV	−0.083	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AMBP–KICH

Open the KICH breakdown →