AMBP

Across TCGA patient cohorts, AMBP mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMBP-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and eEF2. Each is linked with AMBP in more than 2 cancer types. Because this analysis shows association rather than direction, both AMBP-to-partner and partner-to-AMBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AMBP-low versus AMBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBP→partner) and Y-score (partner→AMBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.870	+3.189	.001	.010	3	2
SKCM	4E-BP1 →	+0.396	+3.000	.012	.035	2	3
UCEC	eEF2 →	+0.449	+2.000	.005	.032	3	1
UCEC	EGFR_pY1068 →	-0.358	-3.807	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.119	-2.000	.026	.032	3	1
UCEC	ETS-1 →	+0.292	+2.999	.042	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by AMBP expression — UCEC

Explore this box plot interactively →