ALX4

Across TCGA patient cohorts, ALX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,092 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ALX4-associated GO terms across cancer lineages are Regulation of muscle cell differentiation, Obsolete regulation of histone methylation, and Positive regulation of DNA biosynthetic process. Each is linked with ALX4 in more than 23 cancer types. Because this analysis shows association rather than direction, both ALX4-to-partner and partner-to-ALX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of muscle cell differentiation grouped by ALX4-low versus ALX4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALX4→partner) and Y-score (partner→ALX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of muscle cell differentiation →	+0.048	+0.147	<.001	<.001	3	24
STAD	Obsolete regulation of histone methylation →	+0.073	+0.118	<.001	<.001	3	20
STAD	Positive regulation of DNA biosynthetic process →	+0.058	+0.105	<.001	<.001	3	19
STAD	Body morphogenesis →	+0.063	+0.118	<.001	<.001	3	19
UCS	Positive regulation of epithelial to mesenchymal transition →	+0.057	+1.988	<.001	<.001	3	19
ESCA	Osteoblast differentiation →	+0.066	+0.723	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,092 associations by consensus.

Regulation of muscle cell differentiation by ALX4 expression — STAD

Explore this box plot interactively →