ALX4

Across TCGA pan-cancer cohorts, ALX4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ALX4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ALX4 RNA is repressed in tumor relative to normal tissue. In most cancer types ALX4 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LIHC, and BRCA are the cancer types where ALX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.293	.006	7	view →
LIHC	All	II,III,IV	+0.016	<.001	7	view →
BRCA	All	III,IV	−1.874	<.001	6	view →
KIRC	Male	All	−0.173	.006	4	view →
THCA	Male	All	−0.165	.030	3	view →
UCEC	All	All	−0.456	.015	2	view →
PRAD	All	All	+0.263	.034	2	view →
LUSC	Male	II,III,IV	+0.150	.013	1	view →
LUAD	All	All	+0.136	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ALX4–KICH

Open the KICH breakdown →