ALX4

Across TCGA patient cohorts, ALX4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALX4-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and A-Raf_pS299. Each is linked with ALX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALX4-to-partner and partner-to-ALX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ALX4-low versus ALX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALX4→partner) and Y-score (partner→ALX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.278	+1.904	.009	.029	3	2
UCEC	14-3-3_beta →	-0.086	-2.432	.029	.018	3	1
UCEC	A-Raf_pS299 →	-0.127	-3.321	.006	.010	3	1
UCEC	ERK2 →	+0.176	+1.584	.019	.036	3	1
UCEC	Heregulin →	-0.134	-2.222	.005	.010	3	1
UCEC	MSH2 →	-0.234	-2.449	.009	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

4E-BP1 by ALX4 expression — UCEC

Explore this box plot interactively →