ALX4

Across TCGA cell cohorts, ALX4 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALX4-associated genes across cancer lineages are EDDM3A, IFNL3, and PRSS54. Each is linked with ALX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALX4-to-partner and partner-to-ALX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EDDM3A grouped by ALX4-low versus ALX4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALX4→partner) and Y-score (partner→ALX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EDDM3A →	+0.022	+5.415	<.001	.004	3	1
SKIN	IFNL3 →	+0.052	+5.415	<.001	.004	3	1
BLOOD_Lymphoma	PRSS54 →	+0.046	+4.867	<.001	.009	3	1
OVARY	CDRT15L2 →	+0.022	+5.196	<.001	.005	3	1
LARGE_INTESTINE	EIF3L →	+0.608	+3.087	.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.032	+3.841	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

EDDM3A by ALX4 expression — SKIN

Explore this box plot interactively →