ALX3

Across TCGA cell cohorts, ALX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 972 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ALX3-associated GO terms across cancer lineages are Cell fate determination, Regulation of cell killing, and Defense response to Gram-negative bacterium. Each is linked with ALX3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ALX3-to-partner and partner-to-ALX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell fate determination grouped by ALX3-low versus ALX3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALX3→partner) and Y-score (partner→ALX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Cell fate determination →	-0.163	-0.078	<.001	.004	3	3
BONE	Regulation of cell killing →	-0.115	-1.403	<.001	<.001	3	3
LARGE_INTESTINE	Defense response to Gram-negative bacterium →	-0.108	-0.036	.004	.006	3	3
LUNG_SCLC	Internal peptidyl-lysine acetylation →	+0.162	+1.249	<.001	.001	3	3
LUNG_SCLC	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II →	-0.111	-1.168	.004	.004	3	3
LUNG_SCLC	Trabecula formation →	-0.121	-1.068	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 972 associations by consensus.

Cell fate determination by ALX3 expression — LUNG_NSCLC_LUSC

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