ALX3

Across TCGA pan-cancer cohorts, ALX3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ALX3 data layer compared with 2 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher ALX3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ALX3 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

STAD, DLBC, and READ are the cancer types where ALX3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	II,III,IV	0.193	0.498	<.001	70	view →
DLBC	OS	Tertile	IV	0.147	0.850	.002	69	view →
READ	OS	Quartile	II,III,IV	0.717	0.960	.002	63	view →
ACC	OS	Tertile	All	0.162	0.726	.002	51	view →
KIRC	DFS	Tertile	IV	0.227	0.537	<.001	48	view →
UVM	DFS	Tertile	All	0.801	0.360	.009	37	view →
KIRP	DFS	Tertile	IV	1.000	0.139	.018	24	view →
BLCA	DFS	Quartile	All	0.409	0.654	.002	22	view →
SCLC	DFS	Median	All	0.404	0.114	.003	20	view →
COAD	OS	Tertile	IV	0.172	0.671	.001	18	view →
LGG	DFS	Quartile	All	0.741	0.880	.001	16	view →
TGCT	DFS	Median	All	0.566	0.766	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ALX3–STAD (OS)

Open the STAD breakdown →