ALX1

Across TCGA patient cohorts, ALX1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALX1-associated genes across cancer lineages are A-Raf_pS299, PCNA, and ATM. Each is linked with ALX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALX1-to-partner and partner-to-ALX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ALX1-low versus ALX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALX1→partner) and Y-score (partner→ALX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.139	-3.169	.001	.018	3	2
UCEC	PCNA →	+0.176	+3.321	.026	.009	3	2
UCEC	ATM →	-0.428	-1.502	.010	.030	3	2
UCEC	EGFR_pY1068 →	-0.261	-1.807	.004	.025	3	1
UCEC	MEK1 →	+0.272	+1.847	.043	.008	3	1
UCEC	Notch1 →	+0.174	+2.013	<.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

A-Raf_pS299 by ALX1 expression — UCEC

Explore this box plot interactively →