ALX1

Across TCGA cell cohorts, ALX1 mutation is significantly associated with the RNA expression of many other genes, with 181 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALX1-associated genes across cancer lineages are BCAS2, DPH2, and EPSTI1. Each is linked with ALX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALX1-to-partner and partner-to-ALX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCAS2 grouped by ALX1-low versus ALX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALX1→partner) and Y-score (partner→ALX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BCAS2 →	+0.639	+3.212	<.001	.006	3	1
LARGE_INTESTINE	DPH2 →	+0.557	+3.087	.002	.006	3	1
LARGE_INTESTINE	EPSTI1 →	-1.677	-3.102	.002	.009	3	1
LARGE_INTESTINE	ARL3 →	+0.623	+3.212	.003	.006	3	1
LARGE_INTESTINE	MFAP1 →	+0.606	+3.212	.001	.006	3	1
LARGE_INTESTINE	WDR61 →	+0.475	+3.067	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 181 associations by consensus.

BCAS2 by ALX1 expression — LARGE_INTESTINE

Explore this box plot interactively →