ALPP

Across TCGA patient cohorts, ALPP RNA expression is significantly associated with the go_rna of many other GO terms, with 6,853 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible ALPP-associated GO terms across cancer lineages are Citrulline metabolic process, Positive regulation of intrinsic apoptotic signaling pathway, and Positive regulation of aspartic-type peptidase activity. Each is linked with ALPP in more than 10 cancer types. Because this analysis shows association rather than direction, both ALPP-to-partner and partner-to-ALPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Citrulline metabolic process grouped by ALPP-low versus ALPP-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPP→partner) and Y-score (partner→ALPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Citrulline metabolic process →	+0.075	+0.829	<.001	<.001	3	11
KIRC	Positive regulation of intrinsic apoptotic signaling pathway →	+0.028	+0.033	<.001	<.001	3	10
LUSC	Positive regulation of aspartic-type peptidase activity →	+0.050	+0.444	<.001	<.001	3	10
SCLC	Transcription by RNA polymerase I →	+0.063	+0.256	<.001	<.001	3	10
TGCT	Ribosomal large subunit biogenesis →	+0.049	+1.929	<.001	<.001	3	9
TGCT	Regulation of synaptic transmission, dopaminergic →	+0.076	+1.011	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,853 associations by consensus.

Citrulline metabolic process by ALPP expression — ESCA

Explore this box plot interactively →