ALPP

Across TCGA pan-cancer cohorts, ALPP RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ALPP data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher ALPP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ALPP expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCEC show a favorable association.

MESO, KIRC, and COAD are the cancer types where ALPP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.264	0.490	<.001	137	view →
KIRC	OS	Quartile	II,III,IV	0.338	0.610	<.001	105	view →
COAD	DFS	Quartile	II,III,IV	0.658	0.837	.001	97	view →
SCLC	DFS	Quartile	III,IV	0.801	0.321	.001	70	view →
PAAD	OS	Tertile	All	0.279	0.551	<.001	69	view →
UCEC	OS	Median	III,IV	0.742	0.429	.002	68	view →
LUSC	DFS	Quartile	II,III,IV	0.595	0.837	.001	56	view →
ACC	OS	Tertile	II,III,IV	0.154	0.703	.004	53	view →
UVM	OS	Tertile	All	0.337	0.816	<.001	51	view →
LIHC	OS	Median	II,III,IV	0.472	0.695	<.001	50	view →
KICH	OS	Tertile	II,III,IV	0.093	0.841	<.001	36	view →
THYM	DFS	Quartile	All	0.605	0.955	.015	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ALPP–MESO (OS)

Open the MESO breakdown →