ALPP

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ALPP protein abundance is significantly associated with the RNA expression of many other genes, with 1,580 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPP-associated genes across cancer lineages are LINC01133, BMPR1B-DT, and GID4. Each is linked with ALPP in more than 1 cancer types. Because this analysis shows association rather than direction, both ALPP-to-partner and partner-to-ALPP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALPP versus LINC01133 in LSCC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPP→partner) and Y-score (partner→ALPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCLINC01133 →-2.433-0.674<.001<.00132
OVBMPR1B-DT →+3.271+1.769.003.00132
LSCCGID4 →-1.142-0.798.001.00232
LSCCSOX12 →-1.324-0.873<.001<.00132
UCECDTHD1 →+1.197+1.120.002.00132
LSCCHDAC4 →-1.245-0.837.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,580 associations by consensus.

ALPP vs LINC01133 — LSCC

Per-sample scatter of ALPP vs LINC01133 in LSCC (Pearson r = -0.29).

Explore this scatter interactively →

Exploration