ALPP

Across TCGA patient cohorts, ALPP mutation is significantly associated with the RNA expression of many other genes, with 950 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPP-associated genes across cancer lineages are RNU6-1077P, ZWINT, and PKMYT1. Each is linked with ALPP in more than 2 cancer types. Because this analysis shows association rather than direction, both ALPP-to-partner and partner-to-ALPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1077P grouped by ALPP-low versus ALPP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPP→partner) and Y-score (partner→ALPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1077P →	+0.479	+2.451	<.001	<.001	3	3
SKCM	ZWINT →	+0.680	+3.360	.001	.004	3	3
UCEC	PKMYT1 →	+0.661	+2.716	.005	.003	3	3
LUSC	RNU4-81P →	+0.106	+5.529	<.001	<.001	3	2
LUSC	SEPTIN14P3 →	+0.088	+4.786	<.001	.002	3	2
UCEC	TAF9 →	+0.581	+2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 950 associations by consensus.

RNU6-1077P by ALPP expression — UCEC

Explore this box plot interactively →